Statins work by competitive inhibition of:

a. Inhibition of (HMG Co-A) in the liver, which is the rate limiting step in cholesterol synthesis, is the mechanism of action of statins. They are appropriately prescribed in the evening since the synthesis of cholesterol appears most active overnight. 

The cytochrome p450 is a group of enzymes that control concentrations of drugs and endogenous substances. Succinate Co-A is involved in the Krebs cycle.