Which one of the following physical signs is not associated with cardiovascular disease?

e. Cullen’s sign is periumbilical bruising or yellow-blue discolouration. Originally it was described in ruptured ectopic pregnancy but is more commonly associated with severe, acute pancreatitis. The cause of the discolouration is pancreatic enzymes having tracked along the falciform ligament and digested subcutaneous tissues around the umbilicus. Aortic regurgitation is associated with De Musset’s sign (head-bobbing) and Quinke’s sign (visible nail bed pulsations). Kussmaul’s sign is a rising jugular venous pressure (JVP) on inspiration associated with a diagnosis of constrictive pericarditis and cardiac tamponade. Corrigan’s sign is associated with aortic valve incompetence.