Regarding antiphospholipid syndrome, which of the following autoantibodies is most strongly associated with this condition?

a. Anticardiolipin and lupus anticoagulant antibodies are most strongly associated with antiphospholipid syndrome. Antireticulin antibodies are commonly found in coeliac disease and other enteropathies, antinuclear antibodies are raised in a variety of conditions such as systemic lupus erythematosus (SLE), Sjögren’s syndrome, systemic sclerosis, chronic active hepatitis and rheumatoid arthritis. Anti-Ro antibodies are found in Sjögren’s syndrome and SLE and antineutrophil cytoplasmic antibodies (ANCA) are raised in systemic vasculitides such as Wegener’s granulomatosis, microscopic polyangiitis and Churg–Strauss disease.