Q:

Which of the following is NOT a contraindication to thrombolysis following a diagnosis of an acute MI?

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Which of the following is NOT a contraindication to thrombolysis following a diagnosis of an acute MI?


  1. Previous allergic reaction.
  2. Cerebral infarct 2 years ago.
  3. Suspected aortic dissection.
  4. Heavy vaginal bleeding.
  5. Hypotension.

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b. Contraindications to thrombolysis include:

• Known active bleeding source (e.g. peptic ulcer, active dyspepsia).

• Active menstruation.

• Cerebrovascular accident within 3 months.

• Surgery or head injury within last 3 months.

• Severe hypertension:

– Systolic more than 200mmHG or diastolic more than 100mmHg.

– Must be sustained (e.g. not responding to i.v. nitrates).

• Hypotension:

– Systolic less than 90mmHg and not corrected by atropine (if bradycardia) or other rhythm correction.

• Chest trauma due to prolonged cardiac massage – if CPR more than 5 minutes assess risks with senior staff.

• On warfarin.

• Known or suspected aortic aneurysm.

• Known sensitivity to streptokinase or prior administration within last 24 months (for streptokinase administration only).

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