Q:

Which one of the following is not associated with male infertility?

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Which one of the following is not associated with male infertility? 


  1. Alcoholic cirrhosis.
  2. Germ cell aplasia.
  3. Sperm count of 70 x 109 /litre.
  4. Testis small with prominent Leydig cells.
  5. XXY chromosomal pattern.

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The answer is C. A sperm count of less than 50 x 109 /litre is associated with significant decrease in fertility.

Cirrhosis (A) is associated with increased endogenous oestrogen secretion. Germ cell aplasia (B) is seen in the del Castillo syndrome (or chromatin - negative Klinefelter's syndrome).

Small testes with loss of tubules show pseudohyperplasia of Leydig cells (D). Klinefelter's syndrome is associated with XXY chromosome pattern.

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