For each of the features of alcoholic liver disease listed on the left select the most appropriate association from the list on the right

The answer is E, C, A. The metabolic effects of alcohol on hepatocytes responsible for fatty change are reversible if alcohol is stopped. This is the earliest feature of alcoholic liver damage.

The site of earliest damage in alcoholic liver disease is around the terminal hepatic vein (centrilobular); hepatocyte necrosis in this area is very suggestive of alcohol damage.

Before cirrhosis can be present hepatocyte regeneration has to occur, along with fibrosis; fibrosis on its own is not cirrhosis. Ground glass hepatocytes (B) are a feature of hepatitis B infection. The portal areas (D) are affected later in alcoholic hepatitis when extensive damage has occurred and when cirrhosis is present.