Which ONE of the following is not a predisposing factor in peptic ulcer?

The answer is A. The presence of gastric acid is necessary for the development of peptic ulcer; in the stomach defective mucosal protection appears to be more important than the quantity of acid; in the duodenum gastric hypersecretion is more important.

There is a higher incidence of peptic ulcer in people of blood group O (B). Cigarette smoking (C) and ingestion of certain drugs (E) result in increased risk of peptic (gastric) ulcer. High gastrin secretion (D), i.e., from pancreatic islet cell tumours, results in a fulminating ulcer diathesis (Zollinger-Ellison syndrome).