Q:

Which ONE of the following is a cause of splenic atrophy?

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Which ONE of the following is a cause of splenic atrophy?


  1. Coeliac disease.
  2. Letterer-Siewe disease.
  3. Malaria.
  4. Niemann-Pick disease.
  5. Sarcoidosis.

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The answer is A. In coeliac disease splenic atrophy occurs, with the appearance of Howell-Jolly bodies in erythrocytes. The others all cause splenomegaly.

Letterer-Siewe disease (B) is one form of Histiocytosis-X, in which macrophages proliferate.

Malaria (C) is an example of an infection which causes splenomegaly.

Niemann-Pick disease (D) is a lipid storage disorder.

Sarcoidosis (E) commonly involves the spleen.

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