For each of the defects of coagulation listed on the left select the most appropriate cause from the list on the right

The answer is B, E, C. Deficiency of factor IX results in failure of thromboplastin production from the intrinsic system.

The factor VIII in hemophilia A is functionally abnormal, due to deficiency of factor VIIIC.

Deficient factor VIIIR associated with abnormal platelet adhesion occurs in von Willebrandt's disease; bleeding from minor trauma occurs, but purpura is not a feature.

Combined deficiency occurs in patients on anticoagulant therapy (A). Deficiency of vitamin K (D) can occur in malabsorption and prolonged obstructive jaundice.