For each of the causes of anaemia on the left select the most appropriate association from the list on the right

The answer is A, E, B. In haemolytic anaemia there is destruction of erythrocytes with excessive production of bilirubin which is conjugated and so is not excreted in the urine.

Erythrocytes are usually lost in large numbers following a severe bleed; if bleeding stops there is a brisk marrow response (reticulocytosis); chronic small blood losses result in iron deficiency anaemia.

Pernicious anaemia is due to lack of vitamin B12 and folic acid and is a megaloblastic anaemia; this is an example of a dyshaemopoietic state (as is iron deficiency anaemia).

Idiosyncratic reactions to drugs, i.e., chloramphenicol (C) result in aplastic anaemia in which the marrow is hypocellular.

Myelofibrosis is a myeloproliferative disorder with fibrous replacement of the marrow (D) resulting in anaemia.