Q:

Which ONE of the following is not associated with EB virus infection?

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Which ONE of the following is not associated with EB virus infection?


  1. Burkitt\'s lymphoma.
  2. Carcinoma of the cervix uteri.
  3. Infectious mononucleosis.
  4. Nasopharyngeal carcinoma.
  5. No clinical symptoms.

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The answer is B. Carcinoma of the uterine cervix is associated with infection by another DNA virus (herpes simplex type 2). Burkitt's lymphoma (A) is caused by EB virus which infects B-lymphocytes and occurs in areas where malaria is endemic causing depression of T-cell function.

Infectious mononucleosis (C) is a febrile illness with lymphadenopathy caused by EB virus infection in which there is a vigorous T-cell response; presumably eliminating the transformed B-cells.

Nasopharyngeal carcinoma occurs particularly in China, the tumour cells contain integrated EB virus DNA (D). The majority of people have no detectable clinical illness when infected by EB virus (E).

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