Q:

In which ONE of the following animal species does an experimental model for bladder carcinogenesis by 2-naphthylamine exist?

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In which ONE of the following animal species does an experimental model for bladder carcinogenesis by 2-naphthylamine exist?


  1. Cat.
  2. Dog.
  3. Mouse.
  4. Rat.
  5. Syrian Golden Hamster.

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The answer is B. Epidemiological evidence implicated 2-naphthylamine as a potential bladder carcinogen in the aniline dye industry; only dogs and man convert the noncarcinogenic 2-naphthylamine to carcinogenic 1-hydroxy-2-naphthylamine in the kidney.

This carcinogen is concentrated in the urine and can induce urothelial tumours.

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