For each of the types of amyloid listed on the left select the most appropriate cause from the list on the right

The answer is D, E, C. Fifteen per cent of patients with multiple myeloma have amyloid of immunoglobulin origin derived from immunoglobulin light chains produced by the neoplastic cells.

Amyloid of unknown origin is seen in chronic infections (TB, syphilis, osteomyelitis) as well as in patients with rheumatoid arthritis.

Genetically determined amyloid is rare and is seen particularly around the Mediterranean; there are several different types.

Depression of T-cell function (B) has been suggested as a cause of amyloid but the evidence is contradictory. Bronchopneumonia (A) is an acute infection and is not associated with amyloid; bronchiectasis is a chronic lung condition often complicated by amyloid.