Q:

Which ONE of the following is not a feature of amyloid?

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Which ONE of the following is not a feature of amyloid?


  1. Extracellular fibrillar material.
  2. Filaments of 75 nm diameter.
  3. Intracellular protein.
  4. Present initially in the wall of small blood vessels.
  5. Shows red-green birefringence when stained with Congo Red.

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The answer is C. Amyloid is an extracellular substance (A) consisting of fibrillar material with a characteristic ultrastructural appearance (B). It is seen initially in the walls of small blood vessels (D) in relation to the basement membrane. The most specific histological reaction is the red-green birefringence seen with Congo Red and polarized light microscopy (E).

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