Q:

Which ONE of the following is not a feature of thromboxane A2?

belongs to book: MCQs in Pathology|I L Brown|| Chapter number:8| Question number:34

waelhammad

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2022-12-21

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Which ONE of the following is not a feature of thromboxane A2?

Inhibits platelet adenyl cyclase.
Produced by action of an endothelial cell enzyme.
Produced by conversion of cyclic endoperoxidase by platelets.
Prostaglandin with a half-life of 30 seconds.
Stimulates platelet adhesion and aggregation.

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waelhammad

2022-12-21

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The answer is B. Vascular endothelium is rich in prostacyclin synthetase which produces prostacyclin from the cyclic endoperoxidases. Thromboxane A2 is produced by the action of platelet thromboxane synthetase on cyclic endoperoxides (C). It stimulates platelet adhesion and aggregation (E) by inhibiting platelet adenyl cyclase (A). It is a prostaglandin with a very short half life (D).

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