Q:

For each of the hypersensitivity reactions on the left select the most appropriate association from the conditions on the right

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For each of the hypersensitivity reactions on the left select the most appropriate association from the conditions on the right.

a. Arthus reaction.

b. Cytotoxic antibody reaction.

c. Delayed hypersensitivity reaction.


  1. Asthma.
  2. Auto-immune haemolytic anaemia.
  3. Extrinsic allergic alveolitis.
  4. Infantile eczema.
  5. Tuberculoid leprosy.

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The answer is C, B, E. Artus reaction - extrinsic allergic alveolitis. Immune complex, Arthus type (type 3) reaction is the basis of extrinsic allergic alveolitis (farmer's lung) which is a reaction to bacterial spores growing on mouldy hay.

Cytotoxic antibody reaction - auto-immune haemolytic anaemia. Cytotoxic antibody (type 2) reactions are mediated by antibody which combines with cell surface antigenic determinants usually causing lysis. Auto-immune haemolytic anaemia, idiopathic thrombocytopenic purpura are examples.

Delayed hypersensitivity reaction - tuberculoid leprosy. Delayed hypersensitivity (type 4) reactions are mediated by primed T-lymphocytes; Tuberculoid leprosy, tuberculosis and contact dermatitis are examples.

Asthma and infantile eczema are examples of atopy (type 1).

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