Q:

For each of the components of complement listed on the left select the most appropriate association from the features on the right

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For each of the components of complement listed on the left select the most appropriate association from the features on the right.

a. C3b.

b. C5a.

c. C5b-9 complex.


  1. Chemotactic for neutrophil polymorphs.
  2. Deficiency has no pathological effect.
  3. Inhibits mast cell degranulation.
  4. Macrophage surface receptor.
  5. Target cell plasma membrane injury.

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The answer is D, A, E. C3b - macrophage surface receptor. Macrophages (and polymorphs) have surface receptors for C3b which results in enhanced adherence of these cells to target cells with C3b on their surface.

C5a - chemotactic for neutrophil polymorphs. C5a promotes the emigration and accumulation of neutrophil polymorphs and macrophages.

C5b-9 complex - target cell plasma membrane injury. The final product of the complement cascade is a complex of C5b6789 which is inserted into the target cell plasma membrane resulting in cell lysis.

Deficiency of the early stages of the complement cascade has no pathological effect.

C3a and C5a both stimulate mast cell and basophil degranulation. 

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