Q:

For each of the features of the immunoglobulin molecule listed on the left select the most appropriate association from those on the right

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For each of the features of the immunoglobulin molecule listed on the left select the most appropriate association from those on the right.

a. Fab fragment.

b. Fc fragment.

c. F(ab1 )2 fragment.


  1. C-terminal region.
  2. Consists of heavy chains only.
  3. Consists of light chain and part of heavy chain.
  4. Consists of light chains only.
  5. Pepsin digestion product.

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The answer is C, A, E. Fab fragment - consists of light chain and part of heavy chain. Papain digestion of monomeric immunoglobulin results in the production of two antibodybinding fragments (Fab) which consist of light chains plus part of the heavy chain.

Fc fragment - C-terminal region. Papain digestion of monomeric immunoglobulin results in the production of a fragment consisting of the C-terminal ends of the heavy chains linked together (Fc).

F(ab1 )2 fragment - pepsin digestion product. Pepsin digestion splits the immunoglobulin molecule to produce a fragment consisting of two Fab fragments united by a portion of the Fc fragment.

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