If the following events in the healing of an open wound were in their most probable order which would come fourth?

The answer is D. In a wound healing by second intention (either an open wound or ulcer with loss of tissue, or an infected wound) there is emigration of polymorphonuclear leucocytes, macrophages from the vessels (A) initially with the presence of more abundant fibrinous exudate. Epithelial proliferation (B) is the first sign of healing followed by the proliferation of capillary buds (E) forming granulation tissue with the associated proliferating fibroblasts (D). The fibroblast orientation later becomes parallel to the epithelial surface and contractility of these 'myofibroblasts' (C) helps to reduce the area of the open wound. Scar tissue is usually more prominent than following first intention healing.