For each of the phases of increased vascular permeability in the acute inflammatory reaction noted on the left choose the most suitable association from those on the right

The answer is E, B, C. Immediate sustained response - surrounding tissue and endothelium damaged. This occurs in more severe injury in which vascular damage may be so great as to cause thrombosis and even infarction of the tissues.

Immediate transient response - Leakage occurs through vascular endothelium. In the experimental models only venular leakage occurs in this phase; this suggests endogenous mediator activity.

Delayed prolonged leakage - Leakage occurs through venules and capillaries. Both capillaries and venules leak in this phase, but leakage is confined to the zone of injury suggesting that this is due to direct endothelial injury.