Q:

Which ONE of the following ultrastructural features is believed to allow for the increased permeability of the vascular endothelium in acutely inflamed tissue?

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Which ONE of the following ultrastructural features is believed to allow for the increased permeability of the vascular endothelium in acutely inflamed tissue?


  1. Cytoplasmic micropinocytotic vesicles.
  2. Gaps in endothelial tight junctions.
  3. Gaps in the basement membrane.
  4. Increase in number of phagolysosomes.
  5. No morphological changes.

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The answer is B. There is experimental evidence that gaps appear between vascular endothelial cells during acute inflammation caused by injury and by chemical mediators. These gaps are temporary. Micropinocytotic vesicles (A) do transfer material across cells but are not increased in inflammation.

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