For each of the features on the left select the most appropriate association from the list on the right

The answer is E, C, D. Differentiation is a structural and functional specialization of cells. This is a feature of multicellular organisms, and depends on the selection of genes which each cell type expresses.

Heterotopia is a result of error in intercellular communication in developing fetus. Groups of cell differentiate in a way which is inappropriate to their anatomical location.

Metaplasia is a result of gene activation due to environmental change. This is the change of one differentiated cell type into another, and is often seen as a result of environmental factors, i.e., cigarette smoking

Loss of cellular specialization is dedifferentiation.

Neoplasia comprises the development of a clone of cells growing independently of normal cellular controls.