Q:

Common sites of neuroblastoma metastasis are which of the following?

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Common sites of neuroblastoma metastasis are which of the following?


  1. Lung
  2. Regional lymph nodes
  3. Bone marrow
  4. Cortical bone Liver

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b. Regional lymph nodes

c. Bone marrow

d. Cortical bone Liver

Neuroblastoma metastasizes to both regional lymph nodes and distant sites, most frequently bone marrow and/or cortical bone. The liver and lungs are rarely the site of metastatic spread. Cortical bone involvement as manifested by a positive bone scan is a particularly poor prognostic indicator. The majority of patients present with locally advanced disease at the time of diagnosis.

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