Which of the following variables best predicts prognosis for patients with a recent diagnosis of cutaneous melanoma and no clinical evidence of metastatic disease?

A. Breslow thickness.

DISCUSSION: The prognosis for melanoma is best predicted by the thickness, measured in millimeters (Breslow thickness). Clark's level and ulceration are also predictive, but less so. Gender is a secondary prognostic factor. Skin color may have a mild impact on outcome, but it is primarily a risk factor for developing melanoma.