Which of the following statement(s) is/are true concerning changes in physiology following lung transplant?

b. In single lung transplantation, changes in pulmonary function are seen almost immediately following transplantation

Performing single-lung transplantation in a patient with pulmonary hypertension has been particularly illustrative in demonstrating the potential for reversal of right ventricular dysfunction. As soon as the lung is implanted, the morphology of the right ventricular changes significantly as assessed by transesophageal echocardiography. The intraventricular septum, previously bulging into the left ventricle, immediately assumes the normal position. An increase in contractility of the right ventricle occurs with significant decrease in dilatation. The pulmonary artery pressure immediately decreases and is essentially normal by the time the patient leaves the operating room.

One would also expect significant ventilation perfusion mismatch to occur with ventilation to the native lung occurring preferentially because the native lung is significantly more compliant. Conversely, perfusion should preferentially go to the newly transplanted lung because of lower pulmonary vascular resistance. Despite this occurrence, patients with this operation do well from a functional standpoint. By three months after transplantation, the ventilation/perfusion mismatch narrows. Despite this mismatch, patients do not demonstrate carbon dioxide retention. From a clinical standpoint, improvement in pulmonary function is seen almost immediately after transplantation. The measurement most often used is FEV1 and marked improvement is seen within two weeks. The FEV1 essentially triples and then remains fairly stable. Improvement after bilateral lung transplant is slightly better. Although patients who receive two lungs may do better on pulmonary function tests, this benefit is not translated to significantly better exercise capability