Q:

Which of the following is the one true statement about acute rejection

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Which of the following is the one true statement about acute rejection.


  1. Acute rejection is mediated by T lymphocytes.
  2. Acute rejection is mediated by preformed cytotoxic antibody.
  3. Acute rejection most frequently occurs over months.

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A. Acute rejection is mediated by T lymphocytes.

DISCUSSION: Acute rejection is mediated primarily by T lymphocytes. It occurs over 1 to 3 weeks after placement of an allograft. Hyperacute rejection is mediated by preformed cytotoxic antibody. It occurs within 48 hours of placement of a graft. Chronic rejection is mediated by both T cells and B cells and occurs over months.

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