The presence of donor-reactive lymphocytotoxic antibodies in the serum of a potential kidney transplant recipient:

B. Is a contraindication to kidney transplantation.

DISCUSSION: The presence of donor-reactive antibodies, detected by incubation of the recipient's serum with donor lymphocytes in the presence of complement, results in a “positive crossmatch,” and is a contraindication to renal transplantation. They occur as a result of pregnancy, blood transfusions, or previous organ transplants.