Which of the following distinguish MHC class I from MHC class II antigens?

A. MHC class I and class II antigens are encoded in different regions of the MHC complex

E. MHC class I is recognized by the CD8 glycoprotein, whereas MHC class II is recognized by the CD4 glycoprotein.

DISCUSSION: MHC class I and class II antigens are encoded by genes in different regions of the MHC. The genes and the proteins they encode are homologous to immunoglobulins and thus are members of the immunoglobulin supergene family. MHC class I antigens are expressed on the surface of all cells, whereas MHC class II antigens are largely restricted in expression to antigen-presenting cells and endothelial cells. Both MHC class I and class II antigens are major histocompatibility antigens because their incompatibility in the donor and recipient can lead to very rapid and vigorous rejection of an allograft. The T cells that have antigen receptors specific for MHC class I plus peptide express CD8, a co-receptor that binds to the MHC class I molecules. The T cells that have antigen preceptors specific for MHC class II plus peptide express CD4, a co-receptor that binds to MHC class II molecules.