Q:

Which of the following statements correctly characterize the genetic basis of histocompatibility?

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Which of the following statements correctly characterize the genetic basis of histocompatibility? 


  1. Histocompatibility is determined by a series of genes inherited as a complex and subject to the mendelian rules that characterize recessive traits
  2. Histocompatibility depends in part on the inheritance of histocompatibility genes and in part on the inheritance of Tcell receptor genes
  3. Major histocompatibility genes are polymorphic.
  4. Histocompatibility genes are independently segregating and co-dominant.
  5. Histocompatibility is learned.

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C. Major histocompatibility genes are polymorphic.

D. Histocompatibility genes are independently segregating and co-dominant.

E. Histocompatibility is learned. 

DISCUSSION: Histocompatibility refers to the genetic determinants of graft rejection. The determinants of overwhelming importance consist of a series of histocompatibility genes that segregate independently during meiosis. Each gene has multiple, dominant alleles. Histocompatibility genes and the proteins they encode are highly polymorphic (i.e., they exist in multiple forms).

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