Concerning tolerance to tissue ischemia, the following factor(s) are important variables determining organ failure:

a. Resting metabolic rate

b. Anaerobic glycolysis

d. Efficiency of existing collaterals

Although the specific tolerance of various tissues and organs to ischemic injury is variable, the resting metabolic rate, anaerobic glycolysis and efficiency of existing collaterals are important variables. Autonomic nerve supply does not play a major role.