The clinical manifestations of the patient in the previous question would include:

c. Early pallor is due to both diminished skin blood flow and reflex vasoconstriction

d. Involuntary muscle contraction indicates that restored flow cannot save the extremity

The earliest limb changes in ischemia are in sensory nerves with small nerve fibers having increased sensitivity resulting in loss of sensation to light touch. Sensation to deep pain, pressure and temperature are preserved until late. The paresthesias that occur are in a glove or stocking-like distribution rather than by dermatome. Early pallor is due to decreased blood flow as well as reflex vasoconstriction. Among signs of irreversible limb ischemia are complete anesthesia and involuntary muscle contraction.