Concerning platelet function in vascular disease, the following is/are true:

b. Non-homogeneous distribution of platelets towards the vessel wall is enhanced at increasing shear rates

d. Fibrinogen binding to GPIIb-IIIa is a prerequisite for all platelet aggregation

Platelet adhesion is the initial step in thrombogenesis when subendothelial structures are exposed. Platelet adhesion and their non-homogeneous distribution toward the vessel wall are enhanced at increasing shear rates. The platelet GP which is the principal collagen receptor is GPIa-IIa, GPIb-IX is the one which binds to von Willebrand factor. Fibrinogen binding to GPIIb-IIIa is a prerequisite for all platelet aggregation.