Q:

Concerning the fibrinolytic system the following is/are true:

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Concerning the fibrinolytic system the following is/are true:


  1. Plasminogen is an a-globulin
  2. Fibrin but not fibrinogen is lysed by plasmin
  3. The main inhibitor of plasmin is a2-macroglobulin
  4. TAP is activated during fibrin bonding to plasminogen

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d. TAP is activated during fibrin bonding to plasminogen

Plasminogen is a b-globulin that is converted to plasmin by a number of activators. Plasmin lyses and destroys both fibrin and fibrinogen. The main inhibitor of plasmin is a2-antiplasmin; a2-macroglobulin, ATIII and antitrypsin are less important inhibitors. During fibrin formation, both plasminogen and TAP bind to it specifically, and TAP is activated.

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