Concerning regulation of smooth muscle cell growth, the following is/are true:

b. Fibroblast growth factor (basic) is responsible for the first wave of proliferation in experimental arterial injury

c. The gene for platelet derived growth factor (PDGF) is nearly identical to the oncogene v-sis

The observation that serum derived from whole blood has substantially more growth promoting activity than serum from plasma led to the discovery of PDGF. Basic FGF is responsible for the first wave of proliferation in experimental carotid artery injury. The gene for PDGF is nearly identical to the oncogene v-sis raising the possibility that wound healing and malignant growth might have similarities of regulation. Sympathectomy inhibits the increase in DNA in the media of developing arteries and in hypertension.