Q:

Which of the following statements about lytic agents is/are true?

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Which of the following statements about lytic agents is/are true?


  1. They were first introduced well after the advent of balloon embolectomy
  2. Streptokinase is nonantigenic.
  3. Systemic use is the most effective means of delivery
  4. The interval to reperfusion limits their utility in the treatment of advanced ischemia.

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D. The interval to reperfusion limits their utility in the treatment of advanced ischemia.

DISCUSSION: The balloon catheter technique for embolectomy and thromboembolectomy was introduced in 1963. Lytic agents were undergoing clinical investigation at that time. Streptokinase, derived from streptococci, is antigenic. Urokinase is a naturally occurring enzyme and is not antigenic. Lytic agents have yet to play a major role in the treatment of advanced ischemia in the periphery because of delayed reperfusion, cost, risk of complications, the danger of increased tissue loss.

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