Q:

In the pharmacological management of cardiac arrhythmias, the following is/are true:

0

In the pharmacological management of cardiac arrhythmias, the following is/are true:


  1. Membrane-stabilizing local anesthetics (Class 1) act via sodium channel blockage
  2. Class 1 drugs also shorten the refractory period
  3. b-blocking drugs (Class 2) block the sympathetic nervous system but not circulating catecholamines
  4. Bretylium and other Class 3 drugs inhibit potassium influx into cells
  5. Calcium channel blockers (Class 4) directly affect the SA and AV nodes

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a. Membrane-stabilizing local anesthetics (Class 1) act via sodium channel blockage

d. Bretylium and other Class 3 drugs inhibit potassium influx into cells

e. Calcium channel blockers (Class 4) directly affect the SA and AV nodes

Class 1 drugs are local anesthetics that act via sodium channel blockade, and lengthen the refractory period. Class 2 b-blocking drugs inhibit both the sympathetic nervous system and circulating catecholamines. Class 3 drugs inhibit potassium influx into cells and Class 4 drugs affect slow channel-dependent pacemaker tissue (SA and AV nodes).

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