Q:

A 62-year-old male smoker presents with right anterior chest pain. There is a 3 cm mass attached to the chest wall with radiographic evidence of rib erosion and positive cytology for non-small cell carcinoma. Which of the follow is/are true:

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A 62-year-old male smoker presents with right anterior chest pain. There is a 3 cm mass attached to the chest wall with radiographic evidence of rib erosion and positive cytology for non-small cell carcinoma. Which of the follow is/are true: 


  1. The patient is inoperable due to tumor size and chest wall involvement
  2. Radiation therapy is the preferred initial treatment
  3. Operative resection should be performed with en bloc removal of the tumor and adjacent chest wall as well as a mediastinal lymph node resection
  4. Positive mediastinal nodes will have little effect on survival
  5. The patient would be classified Stage IIIa

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c. Operative resection should be performed with en bloc removal of the tumor and adjacent chest wall as well as a mediastinal lymph node resection

e. The patient would be classified Stage IIIa

Survival after resection for non-small cell lung cancer is related to the stage of the disease with a strong adverse effect from nodal involvement. This is true even for large peripheral tumors that extend into the chest wall as in this case where a 40– 50% survival would be expected in the absence of nodes (T3N0:Stage IIIa) but only a 15% survival with nodal involvement. Radiation therapy would be a postoperative consideration to reduce the incidence of local recurrence. En bloc operative resection of the involved lobe and mediastinal nodes for staging would offer the greatest likelihood of cure.

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