Q:

Clinical features suggestive of myasthenia gravis include all of the following except:

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Clinical features suggestive of myasthenia gravis include all of the following except:


  1. Proximal muscle weakness.
  2. Diplopia.
  3. Sensory deficits of the extremities.
  4. Dysphagia.

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C. Sensory deficits of the extremities.

DISCUSSION: Weakness of proximal weight-bearing muscle groups is the hallmark of the clinical diagnosis of myasthenia gravis. The weakness or fatigue occurs with repetitive activity and improves with rest. The majority of patients (90%) experience ocular muscle involvement, manifested as diplopia or ptosis most easily demonstrated with sustained upward gaze. Cranial nerve involvement is uncommon but can be present, with symptoms of dysphagia, nasal regurgitation, and aspiration. Since myasthenia gravis is a disorder of neuromuscular transmission at the motor end plate, deep tendon reflexes and sensory examination are normal.

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