Compared to segmentectomy or wedge resection, lobectomy for NSCLC is associated with:

D. Lower incidence of locoregional recurrence.

DISCUSSION: The risk of recurrence after surgical resection according to the magnitude of the resection has been analyzed by the Lung Cancer Study Group. In a prospective, randomized trial involving more than 400 patients with T1N0 lung cancer, lobectomy was compared to segmentectomy and wedge resection. There was no significant difference in morbidity and mortality among the procedures. Furthermore, no difference was observed in postoperative pulmonary function between patients who underwent lobectomy and those who underwent lesser procedures. The rate of locoregional recurrence was significantly lower in patients who underwent lobectomy (5%) as compared with those who underwent either segmentectomy or wedge resection (15%). In another study, segmentectomy was compared to lobectomy in patients with Stage I lung cancer. In this study, the rate of locoregional recurrence was lower in patients who underwent lobectomy (5%), as compared with those who underwent segmentectomy (23%). Furthermore, there was a survival advantage in the patients undergoing lobectomy for T2 disease.