Clinical features of breast cancer which are associated with a particularly poor prognosis include:

a. Edema of the skin of the breast

b. Skin ulceration

c. Lateral arm edema

d. Dermal lymphatic invasion

The histologic hallmark of inflammatory breast cancer is dermal lymphatic invasion demonstrable on skin biopsy. The stigmata of this clinical syndrome include breast warmth, tenderness, erythema, and edema.