Q:

A 45-year-old woman presents with a weeping eczematoid lesion of her nipple. Which of the following statement(s) is/are true concerning her diagnosis and management?

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A 45-year-old woman presents with a weeping eczematoid lesion of her nipple. Which of the following statement(s) is/are true concerning her diagnosis and management?


  1. Treatment is with warm compresses and oral antibiotics
  2. Biopsy of the nipple revealing malignant cells within the milk ducts is invariably associated with an underlying invasive carcinoma
  3. The appropriate treatment is mastectomy
  4. The lesion always represents a high-risk disease with a significant risk of subsequent metastatic disease

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c. The appropriate treatment is mastectomy

Paget’s disease is characterized by weeping, eczematoid lesion of the nipple. There is often accompanying edema and inflammation. Biopsy of the nipple reveals malignant cells within the milk ducts. The lesion is invariably associated with an underlying invasive or in situ ductal carcinoma. The prognosis of Paget’s disease is that of the underlying cancer. Standard treatment is mastectomy with axillary lymph node dissection only if invasive cancer is present. 

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