Failure to perform radiation after wide excision of an invasive cancer risks which of the following outcomes?

A. Recurrence of cancer in the ipsilateral breast.

DISCUSSION: Retrospective reviews and prospective surgical trials agree that omission of breast radiation after wide excision leads to a higher rate of ipsilateral breast recurrence. However, survival and the risk of distant disease are not altered in patients treated by excision alone, within the follow-up time of the studies and given their inherent power to detect differences in outcome. Regional node metastasis is not affected by the choice of mastectomy versus wide excision and radiation.