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Which of the following is true about the use of radioiodine to treat hyperthyroidism?

waelhammad
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2022-12-09
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Which of the following is true about the use of radioiodine to treat hyperthyroidism?

  1. If hyperthyroidism is secondary to radioiodine use, it will occur within 2 years of treatment.
  2. There is a markedly increased risk of future thyroid cancer following radioiodine therapy.
  3. The risk of leukemia following radioiodine therapy is approximately 10%.
  4. Mutation abnormalities occur in 15% of fetuses in utero following internal treatment of the mother with radioiodine during pregnancy.
  5. Radioiodine may pass through the placenta and lactating breast to produce hypothyroidism in a fetus or infant.
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waelhammad
2022-12-09
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E. Radioiodine may pass through the placenta and lactating breast to produce hypothyroidism in a fetus or infant.

DISCUSSION: Hypothyroidism secondary to radioiodine therapy increases in frequency with time to 85% after 5 years. There has been no demonstration of an increase in malignancies following radioiodine therapy. Radioactive iodine can cross the placenta and lactating breast to produce hypothyroidism in a fetus or a nursing infant and is, therefore, contraindicated.

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