Q:

Prolactinomas of the pituitary:

waelhammad
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2022-12-09
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Prolactinomas of the pituitary:

  1. Most often produce dysfunctional uterine bleeding in women.
  2. Most commonly produce infertility in men.
  3. When asymptomatic, are best treated surgically early in the microadenoma stage
  4. May enlarge during pregnancy, requiring treatment with bromocriptine or surgery.
  5. Commonly occur in patients with MEN 2.
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waelhammad
2022-12-09
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D. May enlarge during pregnancy, requiring treatment with bromocriptine or surgery.

DISCUSSION: Pituitary prolactinomas are the most common pituitary tumor and cause amenorrhea, galactorrhea, or both in women. Men usually have macroprolactinomas and experience symptoms of a space-occupying lesion of the sella (i.e., headache). A minority of men experience impotence and infertility. Asymptomatic prolactinomas remain stable over time and require observation only. Symptomatic prolactinomas require treatment, usually with bromocriptine. Prolactinomas may enlarge during pregnancy and can produce symptoms requiring treatment with either bromocriptine or surgery. Prolactiomas are seen in as many as 40% of patients with MEN 1.

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