Hypersplenism is associated with which of the following diseases?

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a. Portal hypertension

b. Lymphoma

c. Mononucleosis

d. Systemic lupus erythematosus

e. Gaucher disease 

Hypersplenism is not a specific disease but rather a physiologic state characterized by splenomegaly, a decrease in circulating levels of some blood cells or platelets, bone marrow hypertrophy in response to the decrease in the circulating blood elements, and some degree of improvement by splenectomy. Disease processes associated with secondary hypersplenism include the following:

INCREASED VENOUS PRESSURE

Portal hypertension

Splenic vein thrombosis Severe congestive heart failure

MALIGNANCY

Leukemias (especially chronic)

Lymphoma

CHRONIC INFLAMMATORY DISEASES

Felty syndrome

Systemic lupus erythematosus

Sarcoidosis

METABOLIC ABNORMALITIES

Amyloidosis

Gaucher disease

Niemann-Pick disease

INFECTION

Mononucleosis

Bacterial endocarditis

Parasites

Fungus

OTHER

Myelofibrosis with myeloid metaplasia

Polycythemia vera

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