Which of the following comments does not describe hypersplenism?

E. It is associated with antibodies against platelets.

 DISCUSSION: Hypersplenism was described by Chauffard in 1907 and initially was mostly associated with the syndrome in which a variety of hematologic illnesses, ranging from sickle cell disease to the leukemias, could be found to have improved circulating blood elements if the spleen were removed. Diagnosis of these illnesses has improved, and illnesses once classified as primary hypersplenism now are frequently classified as secondary, as the primary mechanism involved is known. The spleen may enlarge owing to differing pathophysiologic mechanisms, but when it achieves a certain size, it removes all of the main circulating cellular blood elements (red blood cells, white blood cells, platelets). One element may be more deficient than others.