Which of the following statement(s) is/are true concerning focal nodular hyperplasia (FNH)?

a. The lesion predominantly affects young women

c. Radionucleotide scanning can be useful in the specific diagnosis of FNH

Focal nodular hyperplasia (FNH) should not be confused with a hepatic adenoma. Although FNH predominantly affects young women, it is also found in men and children. Unlike adenomas, there is no clear relationship between oral contraceptives and the development of FNH. FNH is most commonly asymptomatic and does not have a propensity to bleed or undergo malignant change. Histologically, FNH contains normal-appearing hepatocytes, bile ducts, and Kupffer cells in distinction to adenomas. Radionucleotide imaging can be useful in diagnosing FNH because FNH is the only lesion that contains Kupffer cells and therefore appears isodense rather than a filling defect. Treatment of asymptomatic patients is conservative when the diagnosis is clear. If there is doubt regarding the diagnosis, then excisional biopsy is indicated for small, easily removable lesions.