Which of the following statement(s) is/are true concerning the morphologic and histologic findings of cirrhosis?
- Micronodular cirrhosis is a pattern typical of chronic alcoholic liver disease
- Mallory bodies and megamitochondria are typical findings of alcoholic cirrhosis
- Bile leaks caused by rupture of bile ducts with extravasation of bile into portal triads is a common finding in post-necrotic cirrhosis secondary to hepatitis
- Large regenerating nodules separated by coarse irregular scars in piecemeal parenchyma necrosis is common in liver disease secondary to chronic active hepatitis
a.Micronodular cirrhosis is a pattern typical of chronic alcoholic liver disease
b.Mallory bodies and megamitochondria are typical findings of alcoholic cirrhosis
d. Large regenerating nodules separated by coarse irregular scars in piecemeal parenchyma necrosis is common in liver disease secondary to chronic active hepatitis
Morphologic classification of cirrhosis includes micronodular, macronodular, and mixed forms. Micronodular cirrhosis is characterized by uniform nodules and scars. The nodules are usually less than 3 mm in diameter and are typically associated with Laennec or nutritional cirrhosis in alcoholics. Post-necrotic cirrhosis is characterized by large regenerating nodules separated by coarse irregular broad as well as thin scars. This pattern is frequently seen in patients with viral hepatitis. Biliary cirrhosis is characterized by a coarsely granular macronodular liver. This condition results from long-standing cholestasis secondary to obstruction of intrahepatic or extrahepatic bile ducts. The most distinctive feature of large duct obstruction is the presence of bile leaks caused by rupture of bile duct with extravasation of bile into portal triads. Portal cirrhosis, which is typically observed in alcoholics, can generally be distinguished histologically by the presence of several specific hepatocellular alterations such as Mallory bodies and megamitochondria.
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