Q:

A surgeon is suspected of having contacted hepatitis B virus via needle stick. Which of the following statement(s) is/are true concerning his diagnosis and outcome?

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A surgeon is suspected of having contacted hepatitis B virus via needle stick. Which of the following statement(s) is/are true concerning his diagnosis and outcome?


  1. Incubation of hepatitis B virus is about two weeks
  2. Jaundice is the first serologic indicator of hepatitis B infection
  3. The patient has about a 10% chance of developing a chronic carrier state
  4. All susceptible household or sexual contacts of the surgeon should receive hepatitis B viral vaccine
  5. The surgeon should receive hepatitis B immunoglobulin as soon as possible after the accidental needle stick

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e. The surgeon should receive hepatitis B immunoglobulin as soon as possible after the accidental needle stick

Hepatitis B viral infection is insidious. The incubation period of the virus is about eight weeks. The first serum indicator of infection by hepatitis B virus is detection of the serum hepatitis B surface antigen (HBsAg) which may proceed the onset of jaundice. In most cases, hepatitis B infection is self-limited and does not progress to chronic hepatitis. However, some 10% of patients with acute hepatitis B viral infection, whether it is clinical or subclinical, will develop a chronic carrier state. The carrier state is defined by the presence of HBsAg in serum for longer than six months. The best method of treatment of hepatitis B viral infection is primary prevention by vaccination. All susceptible household or sexual contacts of a person with a positive serum test for HBsAg should be advised to receive a full course of hepatitis B viral vaccine. Passive prophylaxis with hepatitis B immunoglobulin should be provided to any susceptible contact in whom there is recent potential parenteral exposure such as an accidental needle stick. 

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