Hepatic biotransformation is defined as the intracellular metabolism of endogenous and exogenous organic compounds. Which of the following is/are enzyme families responsible for hepatic bile transformation?
belongs to book: ASIR SURGICAL MCQs BANK|Dr. Gharama Al-Shehri|1st edition| Chapter number:7| Question number:105
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a.Cytochromes P-450
b.UDB-glucuronyl transferases
c.Glutathione-transferases
d.Sulfotransferases
The liver contains enzyme systems that can expose functional groups such as hydroxyl ions and alter the size and solubility of a wide variety of organic and inorganic compounds by conjugation with small polar molecules. The general strategy of the liver is to convert hydrophobic, potentially toxic compounds into hydrophilic conjugates that can then be excreted into bile or urine. There are four general enzyme families responsible for hepatic bile transformation. The cytochromes P-450 catalyze reactions such as oxidation, hydroxylation, sulfoxide formation, oxidative deamination, dealcoholization and dehalogination. Such reactions allow further phase II conjugation with polar groups such as glucuronate, glutathione and sulfate. Glucuronidation is the conjugation of UDB-glucuronic acid to a wide variety of xenobiotics by either esther or ether linkages. The glutathione transferases and sulfotransferases play a role in conjugation of P-450 derivatives. However, the glucuronyl transferase system is the predominant mechanism.
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